L-Citrulline is a non-essential amino acid that is an important intermediate in the urea cycle, functioning along with Arginine and Ornithine to rid the body of ammonia, a byproduct of protein metabolism. Because Citrulline is a precursor of Arginine, it provides a readily available source material for Arginine production, which in turn, can be used for the production of Nitric Oxide (NO). NO plays a fundamental role in vascular function and blood flow. Citrulline therefore, not only supports detoxification pathways, but also supports NO production and a healthy cardiovascular system.
As a dietary supplement, take 1-2 capsules 1 to 2 times daily between meals.
What is Citrulline?
L-Citrulline is an important non-essential amino acid for detoxification of the liver from ammonia (waste product from oxidation), rebuilding and muscle recovery. L-Citrulline is a precursor of L- Arginine and thus plays a role in regulating Nitric Oxide (NO) production.
Citrulline is found in high concentration in the liver and is not a component of any major proteins or enzymes. The amino acid citrulline is required to detoxify the liver from ammonia, which is a waste product of the body from oxidation. Citrulline promotes energy and stimulates the immune system.
This unusual amino acid is formed in the urea cycle by the addition of carbon dioxide and ammonia to L-Ornithine. It is then combined with aspartic acid to form arginosuccinic acid, which is later metabolized into the amino acid L-Arginine.
Citrulline is an amino acid that is part of the L-arginine – NO (nitric oxide) pathway. Citrulline helps to protect against shortages of arginine and can be converted to arginine. Some arginine is converted to NO, which improves arterial blood flow and relaxes blood vessels. NO also has antioxidant functions, helping to protect cardiovascular tissues from oxidative damage leading to atherosclerosis (hardening of the arteries).
Arginine is known to be involved with wound healing, removing excess ammonia from the body, protein and sperm cell synthesis and promoting the secretion of essential hormones (growth hormone, glucagon for energy, insulin for blood sugar control, etc.).
Dietary citrulline is clinically better than ornithine at supporting arginine levels and functions, even though citrulline is converted to ornithine as an intermediate step to its conversion to arginine. Arginine can also be converted back to citrulline.
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